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Newswise In a study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez-Agosto, UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection. This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.

The two-year study was published online October 30, 2014 ahead of print in the journal Current Biology.

Progenitor cells are the link between stem cells and fully differentiated cells of the blood system, tissues and organs. This maturation process, known as differentiation, is determined in part by the original environment that the progenitor cell came from, called the niche. Many of these progenitors are maintained in a quiescent state or “standby mode” and are ready to differentiate in response to immune challenges (such as stress, infection or disease).

Dr. Gabriel Ferguson, a postdoctoral fellow in the lab of Dr. Martinez-Agosto and first author of the study, built upon the lab’s previous research that utilized the blood system of the fruit fly species Drosophila, showing that a specific set of signals must be received by progenitor cells to activate their differentiation into cells that can work to fight infection after injury. Dr. Ferguson focused on two genes previously identified in stem cells but not in the blood system, named Yorkie and Scalloped, and discovered that they are required in a newly characterized cell type called a lineage specifying cell. These cells then essentially work as a switch, sending the required signal to progenitor cells.

The researchers further discovered that when the progenitor cells did not receive the required signal, the fly would not make the mature cells required to fight infection. This indicates that the ability of the blood system to fight outside infection and other pathogens is directly related to the signals sent by this new cell type.

“The beauty of this study is that we now have a system in which we can investigate how a signaling cell uses these two genes Yorkie and Scalloped, which have never before been shown in blood, to direct specific cells to be made,” said Dr. Martinez-Agosto, associate professor of human genetics. “It can help us to eventually answer the question of how our body knows how to make specific cell types that can fight infection.”

Drs. Martinez-Agosto and Ferguson and colleagues next hope that future studies will examine these genes beyond Drosophila and extend to mammalian models, and that the system will be used by the research community to study the role of the genes Yorkie and Scalloped in different niche environments.

“At a biochemical level, there is a lot of commonality between the molecular machinery in Drosophila and that in mice and humans,” said Dr. Ferguson. “This study can further our shared understanding of how the microenvironment can regulate the differentiation and fate of a progenitor or stem cell.”

Excerpt from:
UCLA Gene Discovery Shows How Stem Cells Can Be Activated to Help Immune System Respond to Infection



100 Wild Islands – A Donor's Story
Paul Gauthier shares the story of his role in the 100 Wild Islands Legacy.

By: Nature Trust

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100 Wild Islands – A Donor’s Story – Video



NSA and Surveillance: Do we still feel the same now?
I recently had a debate about the need for surveillance and the role of the NSA. Listen as Steve Doocy with Fox News- Fox and Friends – leads the debate.

By: Morgan Wright

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NSA and Surveillance: Do we still feel the same now? – Video



How india got freedom by Retd Major General G D Bakshi
Major General G.D. Bakshi tells how India got its freedom and highlights the role on Indian National Army, British Indian Army soldiers, Bhagat Singh and Netaji Bose. He demolishes the claim…

By: ToxicTonicVideos

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How india got freedom by Retd Major General G D Bakshi – Video

A couple of weeks ago I on the role SEO plays with your online reputation and another one that I have published last year Online reputation management and SEO. This is a follow-up blog posts outlying the importance of SEO and how it can protect your reputation online. In these tough economic times it is not easy to earn the trust of customers from an online community or from a local consumer …

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Its possible to protect your reputation through SEO: heres how

* Helicopters to fly ballot boxes form remote islands "The single, most important aspect of my role is to deliver a result that is trusted and accepted.

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Helicopters to help speed Scottish vote count



BITNEWS: The Fappening, Jennifer Lawrence Celeb Nude Photo Leak, Apple, Bitcoin, Reddit, 4Chan
FOLLOW THE COIN BITNEWS UPDATE: Tina Hui breaks down the The Fappening, nude photo leaks of Jennifer Lawrence 100+ Female Celebs and the role that Apple, Bitcoin, Reddit, 4Chan, if any. …

By: Follow The Coin

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BITNEWS: The Fappening, Jennifer Lawrence & Celeb Nude Photo Leak, Apple, Bitcoin, Reddit, 4Chan – Video

Former Texas congressman Ron Paul isa favorite among libertarians, even though technically he was a Republican. But his stances on personal liberty set him apart from many fellow Republicans, and he ran as the Libertarian Party nominee in 1988. (Robert F. Bukaty/AP)

Libertarianism might be all the rage, butits adherents might not be as “libertarian” as you think.

That’s the premise of a very interesting new Pew Research Center piece, which notes that there arerelatively fewbig differences between how those who call themselves libertarians and everybody else view the role of government regulation, foreign policy and personal liberty.

Here are the most striking figures (while encouraging you to read the whole piece):

No. 2shows an approximation of New York’s “stop and frisk” policy is the biggest red flag here. The idea that 4in 10 real, genuine libertarians support such a policy in basically equal numbers asthe general populace just doesn’t really pass muster.

Neither does the idea that libertarians would push for a more active U.S. role in foreign affairs than the rest of Americans, as No. 1 shows.

Yes, there are certainly libertarians of all shapes and sizes, with varying degrees of belief in the role of government. But on the whole, being libertarian means erring on the side ofindividual liberty over government regulation and expansion. On all of these measures,libertarians as a whole are pretty much tucked nicely inside the political mainstream — so much so that they almost look like political moderates.

So is that because people don’t know what being a libertarian is, or is it because being a libertarian doesn’t mean what it used to?

Pew tried to control for the former, asking people to correctly identify the over-arching libertarian philosophy. While 14 percent of people claimed to be libertarians, included in the numbers above are only the 11 percent who knew what that actuallymeant.

We would argue, though, that many within that 11 percent still don’t really know what it means.

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The Fix: Its cool to be a libertarian whatever that means



Bitcoin can full-fill the role of cash in a digital society
Brett Scott Networks With IamSatoshi. http://www.iamsatoshi.com/bitcoin-opened-generational-creative-horizon/ https://twitter.com/Iam_Satoshi https://www.fac…

By: Satoshi Pollen

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Bitcoin can full-fill the role of cash in a digital society – Video



“Illuminati Exposed” | TERRIFYING FUTURE FOR HUMANITY IN 2014 BEYOND
TERRIFYING FUTURE for HUMANITY in 2014 and Beyond – ELITE to use TECHNOLOGY to ENSLAVE US SUBSCRIBE OUR BRAND NEW CHANNEL ILLUMINATI EXPOSED!! TAKE AN ACTIVE ROLE WITH US, IN DEFEATING THE…

By: Illuminati Exposed

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"Illuminati Exposed" | TERRIFYING FUTURE FOR HUMANITY IN 2014 & BEYOND – Video



Illuminati Exposed | David Icke – HUMAN RACE, GET OFF YOUR KNEES
Illuminati Exposed | David Icke – HUMAN RACE, GET OFF YOUR KNEES A Project Avalon Interview with Bill Ryan SUBSCRIBE OUR BRAND NEW CHANNEL ILLUMINATI EXPOSED!! TAKE AN ACTIVE ROLE WITH US,…

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Illuminati Exposed | David Icke – HUMAN RACE, GET OFF YOUR KNEES – Video



“Illuminati Exposed” | Jordan Maxwell – Raw Uncut 2014
“Illuminati Exposed” | Jordan Maxwell – Raw Uncut 2014 SUBSCRIBE OUR BRAND NEW CHANNEL ILLUMINATI EXPOSED!! TAKE AN ACTIVE ROLE WITH US, IN DEFEATING THE ILLUMINATI THEIR ALLIES!! Begin…

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"Illuminati Exposed" | Jordan Maxwell – Raw Uncut 2014 – Video



Freedom Project Brain Caf: Hip Hop Saved My Life
Thursday, April 17 @ 7:30pm — Free Everett Stage: 9 Duncan Avenue, Providence, RI 02906 This Brain Caf will examine the role of hip hop in the fight for social justice featuring Tricia…

By: Everett

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Freedom Project Brain Caf: Hip Hop Saved My Life – Video



Friday SEO Chat; What is (and isn't) the role of an SEO?
Recently, friend of the Dojo +Eric Enge , posted a Hangout that asked that question. The answer might surprise you since this debate has been around for years (to get a sense, go through…

By: SEO Training Dojo

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Friday SEO Chat; What is (and isn’t) the role of an SEO? – Video

Byline: RNLI lifeguards will be back on Jerseys beaches for a fourth season from Saturday (17 May) when safety patrols start. Page Content: This year is particularly significant as its the first year a local Jersey lifeguard has stepped up to the role of lifeguard supervisor. Will Glenn, 22, has taken over the position bringing invaluable knowledge of the local beaches to the management team …

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RNLI-lifeguards-return-for-their-fourth-season-of-successful-lifesaving-in-Jerse



[Liberty-RP] {RACER'Z} Braquage foir
On tait tranquille dans un braquage qui tait au dbut ROLE PLAY jusqu' que la LSPD s'amne et foutent la merde..

By: Rayan Rising

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[Liberty-RP] {RACER’Z} Braquage foir – Video



Interview with Juliano Torres of Students for Liberty Brazil
The state of liberty in Brazil and the role of the student movement. Interviewed by Jeffrey Tucker.

By: Liberty.me

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Interview with Juliano Torres of Students for Liberty Brazil – Video

Mar 232014

HANDSOME Korean actor and singer Seo In Guk thinks that being able to see ghosts is a unique and incredible power. It would be great if I have such power and can use it to befriend ghosts, but it probably wont change the fact that Im scared of them, he says in a recent interview.

Whatever it is, I still wouldnt want to see them.

Seo recently starred in the highly acclaimed Korean drama The Masters Sun, a supernatural romance series whose reruns are now airing on Sundays at 8.45pm on ONE HD (Astro channel 393). Thankfully, his character is not the one with the ability to see spirits. He plays Kang Woo, a former soldier hired as the head of security at a shopping mall which Joo Joong-won (So Ji Sub) runs.

Kang Woos neighbour, Tae Gong Shil (Gong Hyo Jin), suddenly has the ability to see ghosts after being in an accident. The evil spirits want her to fulfil their last wishes and this leads her to become an outcast. She discovers that the spirits are banished when she touches Joong Won, so she begins working for him. They become closer over time, and this doesnt sit well with Kang Woo who has developed feelings for Gong Shil.

Kang Woo might be a romantic, someone who looks gentle on the outside. But he is actually a tough and charismatic man. His level-headed character is what I like most about him, Seo says.

Similar to Kang Woo, Seo has experienced a one-sided love before. I made an elaborate confession but it didnt work out. It broke my heart.

Gong Shil is older than Kang Woo; and Seo says he doesnt mind dating someone older. I think that love has no age boundaries. I would prefer an intelligent woman over a pretty one.

Meanwhile, when Gong Shil wrecks her high school rival Tae Yi Ryungs (Kim Yoo Ri) wedding, the latter fights back by seducing Joong Won, but finds herself attracted to Kang Woo instead. Working with more experienced actors So, Gong and Kim have been a wonderful experience for Seo, who says they became close during filming. The atmosphere was great, cheerful and harmonious. I felt at ease working with them.

The series was filmed in mid-June last year, which was summer in Korea. My role as a security officer required me to be decked in formal wear even for outdoor filming locations. I cant forget how hot it was.

To prepare for the role, Seo underwent a strict diet and lost 10kg over three months. He is a charismatic security officer and to fit the role, I had to work out and go on a diet. I also studied the role to ensure that I am convincing enough as a security officer.

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SHOWBIZ: Spirited approach from Seo



Project Mercury: Freedom Seven – 1961 National Aeronautics and Space Administration Documentary
This NASA film was produced in 1961 and depicts the early stages of Project Mercury, with a focus on Astronaut Alan Shepard and his role in becoming the firs…

By: Ella's Archives

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Project Mercury: Freedom Seven – 1961 National Aeronautics and Space Administration Documentary – Video



Daniel Bruhl talks about the freedom of playing the blunt Niki Lauda in 'Rush'
Daniel Bruhl talks about his role in the upcoming Ron Howard film 'Rush'.

By: HitFix

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Daniel Bruhl talks about the freedom of playing the blunt Niki Lauda in ‘Rush’ – Video



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